Symbol
Name
ID

Nf1
neurofibromin 1
MGI:97306

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Juvenile myelomonocytic leukemia	Abnormality of the lymphatic system
Disease(s) Associated with NF1	Leukemia	Acute myeloid leukemia	Chronic myelogenous leukemia	Juvenile myelomonocytic leukemia	Abnormality of the lymphatic system
acute myeloid leukemia
juvenile myelomonocytic leukemia
neurofibromatosis 1
neurofibromatosis-Noonan syndrome

Mouse Phenotypes

increased mast cell degranulation

enlarged spleen

abnormal myelopoiesis

increased neutrophil cell number

increased granulocyte number

increased lymphocyte cell number

increased osteoclast cell number

increased monocyte cell number

increased leukocyte cell number

abnormal microglial cell morphology

abnormal myeloid leukocyte morphology

abnormal spleen morphology

absent spleen germinal center

spleen fibrosis

abnormal mast cell physiology

abnormal lymphatic vessel morphology

dermatitis

Availability

Mouse Genotype

Nf1^tm1Fcr/Nf1^tm1Fcr

Nf1^tm1Tyj/Nf1⁺

Nf1^{tm1c(KOMP)Wtsi}/Nf1^{tm1c(KOMP)Wtsi}
Tg(Dhh-cre)1Mejr/0 (conditional)

Nf1^tm1Par/Nf1^tm1Par
Tg(Prrx1-cre)1Cjt/0 (conditional)

Nf1^tm1Par/Nf1^tm1Par
Tg(Mx1-cre)1Cgn/0 (conditional)

Nf1^tm1.1Kest/Nf1^{tm1c(KOMP)Wtsi}
Tg(Dhh-cre)1Mejr/0 (conditional)

Nf1^tm1Fcr/Nf1^tm1Par
Tg(Tek-cre)1Ywa/0 (conditional)

Nf1^tm1Par/Nf1^tm1Fcr
Tg(GFAP-cre)#Gtm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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